In her first HBO comedy special since 2013’s acclaimed “Sarah Silverman: We Are Miracles,” Sarah Silverman showcases her fearless chutzpah in a performance filmed at The Wilbur Theater in Boston.

In the isolated desert of Winslow, Arizona at NASA’s Moon Base Simulator, three eager astronauts—Skip, Rook and their leader Cap—attempt to qualify for their first lunar mission. They encounter many…